On sufficient substantiation for maximum permissible level of zilpaterol in meat products

نویسندگان

چکیده

The Joint FAO/WHO Expert Committee recommends the maximum permissible level of zilpaterol in meat to be fixed at 0.5 µg/kg. This is substantiated by results analysis described several research works. Nevertheless, substantiation provided for this recommended standard requires a detailed discussion. In study, we aimed analyze suggestions on (MPL) as per health risks consumers. Our revealed that no observed adverse effect (NOAEL) and lowest (LOAEL) were established allowing negative effects various organs systems body. under acute exposure was taken baseline establishing MPL. produces nervous system (developing tremor). However, modifying factors used MPL development have not been supported with solid argument. We also LOAEL identified much lower than NOAELs other chronic exposure. Therefore, aforementioned seem rather controversial. It necessary consider another additional factor, which wide prevalence cardiovascular diseases among adult population risk cause their development. potential are less important should note they reliably detected both experiments. modeled caused consuming products residual levels; dynamics. modeling experiment an impermissible outcomes occurred even levels close limit sensitivity. Consequently, it seems premature accept being suggested present. cut its down detection.

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ژورنال

عنوان ژورنال: Health risk analysis

سال: 2022

ISSN: ['2542-2308']

DOI: https://doi.org/10.21668/health.risk/2022.4.10.eng